Bone: A Treatise is a series of nine volumes devoted to providing the most up-to-date, comprehensive and authoritative coverage of all aspects of bone. Chapters have been written by 127 respected authors, all of whom are ctively engaged in basic, applied and clinical bone research. The nine volumes within this series are organized thematically. Each volume integrates structure, function, biochemistry, metabolism and the molecular and clinical aspects of a particular aspect of the biology of the bone. Volume 8 covers mechanisms of bone growth and development. Topics discussed include: the synthesis of endochondrial and intratendinous ossification; bone proteins; how transmembrane signalling mediates osteoinduction; and cellular mechanisms of bone formation.