Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis

The binding of apoA-I to two functionally opposing PM microdomains, ABCA1 and DSC1 domains, suggests that HDL biogenesis and PM cholesterol levels may be regulated by the relative abundance of the two domains and that novel HDL biogenic therapies may be developed by targeting DSC1.