牙周炎
牙槽
医学
海马结构
内科学
内分泌学
胶质纤维酸性蛋白
高架加迷宫
肿瘤坏死因子α
免疫组织化学
焦虑
牙科
精神科
作者
Eric Francelino Andrade,Débora Ribeiro Orlando,Júlia Ariana Souza Gomes,Renata de Carvalho Foureaux,R. A. Costa,Mary Suzan Varaschin,Gustavo Puggina Rogatto,Rodrigo Ferreira de Moura,Luciano José Pereira
摘要
To evaluate the effects of physical training on inflammatory and behavioural parameters of Wistar rats with periodontal disease (PD).Twenty four animals were distributed in a 2 × 2 factorial design (with and without exercise, with and without PD). Trained animals swimmed one hour daily during 8 weeks. PD was induced by ligature 14 days before the end of experiment, and in the last week, all animals were submitted to the Marble Burying Test. Histomorphometric analyses of the mandibles and expression of cytokines were conducted by Western blotting. We also evaluated the morphometry of hippocampal astrocytes using anti-glial fibrillary acidic protein antibody.Physical training attenuated bone loss and epithelial attachment loss levels of rats with PD. Trained animals with PD presented lower TNF-α expression in periodontal tissues while IL-10 was increased. TNF-α/IL-10 ratio was lower in trained animals with PD compared to those with induced periodontitis. PD increased anxiety-like behaviour, and physical training attenuated this parameter. Exercise increased the ramifications of hippocampal astrocytes in rats without PD.Exercise decreased anxiety behaviour, inflammatory proteins expression and bone loss in rats with PD.
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