Study of the variation of flash visual evoked potential in preterm low birth weight infants and its related influencing factors

Objective To study the variation of flash visual evoked potential(FVEP)in preterm low birth weight infants and its related influencing factors.Methods FVEP was performed in low birth weight and very low birth weight infants hospitalized with perinatal complications from November 2007 to December 2008,and a group of preterm low birth weight infants without any complication as well as normal term infants group served as controls.A logistic regression analysis for the perinatal factors was applied subsequently in the premature infants with abnormal main wave P1 and then regression equation was established by related factors screening.Results The mean latency periods of N1,P1,N2 wave were(181.4±26.7)ms,(217.3±26.5)ms,(249.2±26.5)ms in the very low birth weight group,and(177.6±18.7)ms,(217.6±23.2)ms,(250.1±20.4)ms in the low birth weight group,comparing to(158.9±32.1)ms,(199.9±13.3)ms,(232.9±16.7)ms in the low birth weight controls.We observed that the latency period of each wave were longer in the very low birth weight or low birth weight infants than that in the terms.Meanwhile,the latency periods of main wave P1 were detected longer in testing groups than in that of the controls.And there were significant differences respectively(P0.001).As to the abnormal rate,it's also detected higher in testing groups than in the low birth weight controls.The major related influencing factors in low birth weight infants with abnormal main wave was brain injury.Conclusion Abnormal rate of FVEP was detected higher in the preterm low birth weight infants with complications in the perinatal period,and the variation was closely related to brain injury.