异质性
生物
秀丽隐杆线虫
线粒体
线粒体DNA
遗传学
未折叠蛋白反应
粒体自噬
突变
细胞生物学
计算生物学
基因
细胞凋亡
自噬
作者
Ye Tian,Carsten Merkwirth,Andrew Dillin
标识
DOI:10.1016/j.tcb.2016.06.006
摘要
The mitochondrial unfolded protein response (UPRmt) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPRmt activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences. This study extends our understanding of the UPRmt and provides a possible therapeutic target for diseases associated with mtDNA mutations. The mitochondrial unfolded protein response (UPRmt) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPRmt activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences. This study extends our understanding of the UPRmt and provides a possible therapeutic target for diseases associated with mtDNA mutations.
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