Analysis of serum sex hormone in 69 patients with oligospermia and azoospermia

Objective To investigate the clinical value of the determinations of serum sex hormone in patients with oligospermia and azoospermia.Methods Serum sex hormone levels of 21 patients with azoospermia, 48 patients with oligospermia (there were 13 patients with severe oligospermia among them) and 25 healthy men with normal semen as normal control were determined by chemiluminescent immunoassay (CLIA).Results FSH and LH in azoospermia and severe oligospermia were all significantly higher than that in normal semen (P0.01), and FSH was raised more highly than LH each other. FSH and LH in oligospermia were higher than that in normal semen, but the differences were not significant (P0.05). Compared with that in normal semen, in azoospermia, oligospermia and severe oligospermia, PRL was significantly higher (P0.01), T was significantly lower (P0.01), but E2 and P did not alter significantly (P0.05), respectively. The rates of which showed FSH increasing, LH increasing, PRL increasing, and T reducing respectively were 66.7%, 61.9%, 28.6% and 42.9 % in azoospermia, and 53.8%, 38.5%, 30.8% and 38.5% in severe oligospermia. The rates of which showed FSH, LH and T reducing together were 14.3% in azoospermia and 7.7% in severe oligospermia; the rates of which showed FSH, LH increasing but T in the normal reference range were 38.1% in azoospermia and 23.1% in severe oligospermia; the rates of which showed FSH, LH increasing but T reducing were 23.8% in azoospermia and 15.4% in severe oligospermia; the rates of which showed FSH, LH and T in the normal reference range together were 19.0 % in azoospermia and 23.1% in severe oligospermia.Conclusion The determination of serum sex hormone is of clinical importance for the etiological analysis, the treatment and the prognostic judgement of oligospermia (severe oligospermia especially) and azoospermia.