河马信号通路
Wnt信号通路
生物
细胞生物学
连环素
癌变
串扰
细胞质
干细胞
信号转导
遗传学
癌症
光学
物理
作者
Fei Xu,Jin Zhang,Duan Ma
出处
期刊:Yichuan
[China Science Publishing & Media Ltd.]
日期:2014-04-25
卷期号:36 (2): 95-102
被引量:3
标识
DOI:10.3724/sp.j.1005.2014.00095
摘要
Wnt/β-catenin and Hippo/YAP pathways are known to be important for development, growth, organogenesis, and maintenance of adult stem cells. In mammalian cells, Wnt signalling stabilises cytoplasmic β-catenin through several core molecules to promote β-catenin to enter the nucleus, thus delivers the growth -promoting signal. Hippo kinase cascade pathway promotes cytoplasmic localization of YAP/TAZ, which restricts cell proliferation and induces apoptosis. Deregula-tion of these two pathways could lead to tumorigenesis. Growing data indicate that these two pathways influence each other in a number of ways to properly regulate tissue growth and repair. Elucidating the regulatory mechanism and biological functions of Hippo/YAP and Wnt/β-catenin pathways might reveal potential targets for tumor therapeutic intervention. In this review, we discuss on the interactions between Wnt/β-catenin and Hippo/YAP pathways, and how these interactions contribute to tumorigenesis.
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