医学
内科学
血压
内分泌学
收缩(语法)
缺氧(环境)
主动脉
氧气
有机化学
化学
作者
Yujun Cai,Xuefeng Deng,Xuechou Zhou,Yonghua Zheng,X Wang,Binhui Liang,Qiuyin Cai,Yunyun Yang
出处
期刊:PubMed
日期:1993-09-01
卷期号:8 (3): 125-8
摘要
The mechanism of hypoxic moderation of systemic systolic blood pressure was investigated in spontaneously hypertensive rats (SHR). Male SHR rats were divided into hypoxic (H, 5000 m for 15 d) and normoxic (N) groups. The systemic blood pressure of SHR-H (24.9 +/- 1.2 kPa) was found to be 3 kPa lower than that in SHR-N (27.0 +/- 1.3 kPa) (P < 0.05). This protective effect may have been related to the adaptive changes in vascular reactivity which manifested as an increase in the relaxation response of the aorta to ACh (P < 0.01) and a drop in its contraction in response to 5-HT (P < 0.05) following hypoxic exposure. The hypoxic moderating effect against the development of systemic hypertension may have also been related to the increased plasma levels of ANP observed.
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