Simultaneous qualitative and quantitative analysis of tyloxapol in tobramycin eye drops by LC-Q-TOF and HPLC-ELSD

= 0.999), with favorable accuracy (recovery rate = 99-106%), precision (repeatability RSD ≤ 2.2%, intermediate precision RSD ≤ 1.6%), specificity, and solution stability. The combination of Q-TOF MS and HPLC-ELSD can be applied for the qualitative and quantitative analysis of excipients in pharmaceutical formulations, supporting the reverse engineering process in generic drug development.