SECONDARY METABOLITES FROM A MARINE-DERIVED FUNGUS Penicillium chrysogenum 045-357-2

Marine fungi represent a potential source for natural products in the future due to the incredible diversity of chemical compounds. In our previous investigation to search new antimicrobial agents from marine-derived fungi, we isolated fungal strain Penicillium chrysogenum 045-357-2 from a soft coral sample collected from Ca Na Bay, Ninh Thuan, Vietnam. The fungus showed high antibacterial activity and was selected for further study. By various chromatography separations, two compounds including andrastinA (1) and citreohybridonol (2) were obtained from the ethyl acetate extract of culture medium of this strain. Their chemical structures were determined by analysis of 1D and 2D NMR spectra and high-resolution mass spectroscopic data, as well as by comparison of the corresponding data to those previously reported in the literature. The compound 2 exhibited antibacterial activity towards Bacillus cereus ATCC 11778 and Streptoccocus faecalis ATCC 19433 with Minimal Inhibitory Concentration (MIC) values of 32 and 64 μg/ml, respectively; however, antibacterial activity was not detected in the compound 1. This is the first report on these compounds of marine fungal strain P. chrysogenum isolated in Vietnam.