壳聚糖
氟苯尼考
吸附
药物输送
海水
分子印迹聚合物
色谱法
化学工程
自愈水凝胶
毒品携带者
材料科学
核化学
傅里叶变换红外光谱
化学
控制释放
纳米技术
选择性
有机化学
高分子化学
抗生素
生物化学
催化作用
工程类
地质学
海洋学
作者
Fang Li,Ziru Lian,Chunxia Song,Changzi Ge
标识
DOI:10.1016/j.marpolbul.2021.113068
摘要
Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater. The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses. The swelling behavior, adsorption capability, and selectivity for FF were investigated. The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF. The release studies of MIPs as drug delivery carriers were evaluated in natural seawater. The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation. The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
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