生物
抑制性突触后电位
兴奋性突触后电位
电生理学
作者
Kai Yi Wang,Jei Wei Wu,Jen Kun Cheng,Chun Chung Chen,Wai Yi Wong,Robert G. Averkin,Gábor Tamás,Kazu Nakazawa,Cheng Chang Lien
出处
期刊:Cell Reports
[Elsevier]
日期:2021-09-14
卷期号:36 (11): 109702-
标识
DOI:10.1016/j.celrep.2021.109702
摘要
Modulation of hippocampal dentate gyrus (DG) excitability regulates anxiety. In the DG, glutamatergic mossy cells (MCs) receive the excitatory drive from principal granule cells (GCs) and mediate the feedback excitation and inhibition of GCs. However, the circuit mechanism by which MCs regulate anxiety-related information routing through hippocampal circuits remains unclear. Moreover, the correlation between MC activity and anxiety states is unclear. In this study, we first demonstrate, by means of calcium fiber photometry, that MC activity in the ventral hippocampus (vHPC) of mice increases while they explore anxiogenic environments. Next, juxtacellular recordings reveal that optogenetic activation of MCs preferentially recruits GABAergic neurons, thereby suppressing GCs and ventral CA1 neurons. Finally, chemogenetic excitation of MCs in the vHPC reduces avoidance behaviors in both healthy and anxious mice. These results not only indicate an anxiolytic role of MCs but also suggest that MCs may be a potential therapeutic target for anxiety disorders.
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