材料科学
纤维蛋白
粘附
凝结
涂层
凝血时间
体内
化学工程
生物医学工程
色谱法
复合材料
高分子化学
医学
免疫学
化学
工程类
生物技术
精神科
生物
作者
Wenzhao Zhang,Jianzhou Wu,Lisha Yu,Hao Chen,Dan Li,Chaojie Shi,Liping Xiao,Jie Fan
标识
DOI:10.1021/acsami.1c10891
摘要
To solve the problem of strong adhesion and excessive blood loss caused by the use of hydrophilic zeolite gauze (Z-Gauze) in uncontrollable bleeding, we have modified the surface of commercial Z-Gauze with a paraffin coating and prepared a hydrophobic dressing PZ-Gauze. After paraffin coating, the adhesion of Z-Gauze was reduced without an obvious decrease in coagulation activity. The clotting time of the hydrophobic PZ-Gauze was reduced from 378.3 to 154.6 s compared with that of cotton gauze, and the peeling force was decreased from 348.8 to 84.7 mN compared with that of Z-Gauze. Besides, PZ-Gauze can efficiently cut down the blood loss during treatment. On the basis of in vitro and in vivo experiments, it is confirmed that surface hydrophobic modification does not change the procoagulant performance because of the maintained cation exchange capacity of zeolites, and the reduced blood loss as well as enhanced difficulty for fibrin adhesion is attributed to its hydrophobicity. This is different from the traditional gauze procoagulant theories, where gauze hydrophilicity and procoagulant performance are always positively correlated.
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