铑
芳基
化学
区域选择性
催化作用
三氟甲磺酸
组合化学
溴化物
有机化学
烷基
作者
Clément Jacob,Julien Annibaletto,Jie Peng,Ruopeng Bai,Bert U. W. Maes,Yu Lan,Gwilherm Evano
标识
DOI:10.1002/anie.202403553
摘要
An efficient and broadly applicable rhodium‐catalyzed direct ortho‐arylation of anilines with aryl iodides relying on readily available aminophosphines as traceless directing groups is reported. Its scope and functional group compatibility were both found to be quite broad as a large variety of both aminophosphines and (hetero)aryl iodides, including complex ones, could be utilized. The ortho‐arylated anilines could be obtained in high average yields, without any competing diarylation and with full regioselectivity, which constitutes a major step forward compared to other processes. The reaction is moreover not limited to aryl iodides, as an aryl bromide and a triflate could be successfully used, and could be extended to diarylation. Mechanistic studies revealed the key and unique role of the aminophosphine, acting not only as a substrate but also as a ligand for the rhodium catalyst.
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