突触可塑性
佩里
神经科学
长时程增强
可塑性
神经可塑性
化学
生物
细胞生物学
医学
物理
内科学
受体
生物化学
热力学
作者
Gabriele Chelini,Hadi Mirzapourdelavar,Peter Durning,David Baidoe-Ansah,Manveen K. Sethi,Sinead M. O’Donovan,Torsten Klengel,Luigi Balasco,Cristina Berciu,Anne Boyer-Boiteau,Robert E. McCullumsmith,Kerry J. Ressler,Joseph Zaia,Yuri Bozzi,Alexander Dityatev,Sabina Berretta
出处
期刊:Cell Reports
[Elsevier]
日期:2024-05-01
卷期号:43 (5): 114112-114112
标识
DOI:10.1016/j.celrep.2024.114112
摘要
Recent findings show that effective integration of novel information in the brain requires coordinated processes of homo- and heterosynaptic plasticity. In this work, we hypothesize that activity-dependent remodeling of the peri-synaptic extracellular matrix (ECM) contributes to these processes. We show that clusters of the peri-synaptic ECM, recognized by CS56 antibody, emerge in response to sensory stimuli, showing temporal and spatial coincidence with dendritic spine plasticity. Using CS56 co-immunoprecipitation of synaptosomal proteins, we identify several molecules involved in Ca2+ signaling, vesicle cycling, and AMPA-receptor exocytosis, thus suggesting a role in long-term potentiation (LTP). Finally, we show that, in the CA1 hippocampal region, the attenuation of CS56 glycoepitopes, through the depletion of versican as one of its main carriers, impairs LTP and object location memory in mice. These findings show that activity-dependent remodeling of the peri-synaptic ECM regulates the induction and consolidation of LTP, contributing to hippocampal-dependent memory.
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