Assembling a multi-component and multifunctional integrated filament scaffold based on triaxial 3D bioprinting technology

Currently, most scaffolds produced by 3D printing is based on a single material which limits their wide application in the medical field. In this study, a multi-component and multifunctional shell-core filament 3D scaffold was designed and subsequently produced by triaxial bioprinting technology using sodium alginate, gelatin, collagen, chitosan and platelet-rich plasma (PRP) as biological raw materials. The resulting filamentous 3D scaffold exhibited excellent water absorption and retention capacity, good biocompatibility as well as antibacterial effects. In addition, compared with clinically-used PRP-gel, the filamentous 3D stent could effectively reduce the frequency of PRP administration by 50–75% during wound treatment while also showing better therapeutic effects.