氧化应激
细胞凋亡
脂肪变性
酒精性肝病
酒
抗氧化剂
肝损伤
化学
肝硬化
脂肪肝
脂质过氧化
药理学
肝细胞
乙醇
传统医学
医学
生物化学
内科学
疾病
作者
Xinmei Gao,Wen-Han DONG,Chunlei Xia,Zhuo-Yi Ma,Ying Wang,Setrerrahmane SARRA,Han-Mei XU,Weiyan Qi
标识
DOI:10.1016/s1875-5364(22)60181-x
摘要
Alcohol liver disease (ALD) has become a global threat to human health. It is associated with a wide range of liver diseases including alcohol fatty liver, steatosis, fibrosis and cirrhosis, and finally leads to liver cancer and even death. Centranthera grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD, but no research about its mechanism is available. This study evaluated the hepatoprotective effect and mechanism of C. grandiflora against alcohol-induced liver injury in mice. We found that the ethanol extracts of C. grandiflora (CgW) alleviated the alcohol-induced liver injury, enhanced the levels of antioxidant enzymes, and reduced the amount of lipid peroxides. CgW also affected cell apoptosis by inhibiting the activity of Bax, cleaved-caspase 3 and cleaved-caspase 9, and increasing the activity of Bcl-2. In conclusion, the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time. This study suggested that C. grandiflora is a promising herbal medicine for ALD treatment.
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