炔基化
化学
催化作用
铜
配体(生物化学)
组合化学
有机化学
受体
生物化学
作者
Jianlin Chun,Yukun Li,Xiaofei Xie,Kang Guo,Daoyuan Zhao,Kang Chen,Yingguang Zhu
标识
DOI:10.1021/acs.orglett.3c03158
摘要
A photoinduced copper-catalyzed enantioconvergent remote alkynylation of N-hydroxyphthalimide esters with terminal alkynes via 1,4-heteroaryl migration has been developed. A broad scope of heteroaryl-tethered chiral alkynes has been synthesized with good regio- and enantioselectivities. The chiral-ligand-coordinated copper species plays a dual role as both the photoredox and cross-coupling catalyst. This methodology provides a new platform for enantioconvergent remote alkynylations.
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