Ultrasmall platinum nanoclusters densely immobilized on hairy metal organic framework for nonenzymatic glucose detection

Rational design of non-enzymatic nanomaterials that possess the similar functions to natural enzymes holds great promise in chemical and biological molecule detection. In this work, a non-enzymatic electrochemical biosensor for detection of glucose was developed based on poly(2-vinylpyridine) (P2VP) grafted UiO-66 metal organic framework decorated with ultrafine platinum nanoclusters (PtNCs). The as-fabricated UiO-66-g-P2VP/PtNCs nanocomposite was then placed on an indium tin oxide (ITO) electrode to construct non-enzymatic glucose biosensor for electrochemical detection of glucose in alkaline electrolyte. The resulting UiO-66-g-P2VP/PtNCs/ITO modified electrode showed two linear responses over glucose concentration ranging of 0.01–5 mM and 5–18 mM with a low detection limit of 2.18 μM (S/N = 3). Moreover, the UiO-66-g-P2VP/PtNCs/ITO serving as an electrochemical biosensor was successfully applied to the rapid determination of glucose in human serum sample with a desirable result. Our findings pave the way for design and development of a promising artificial enzyme for the construction of high performance sensing platform.