Homogeneous and Recyclable Palladium Catalysts: Application in Suzuki–Miyaura Cross-Coupling Reactions

This work demonstrates the use of catalytic systems that take advantage of a metalla-GAP strategy (GAP = group-assisted purification) in homogeneous catalysis. This discovery allows simple reclamation and reuse of homogeneous metal catalysts. Homogeneous catalysis has many appealing properties, such as high chemo-, regio-, and stereoselectivity, an abundance of suitable catalysts to choose from, and generally mild reaction conditions. However, many homogeneous catalyst systems cannot be used in more practical, industrially relevant settings because of poor separability between products and catalyst. The m-GAP strategy is demonstrated in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions. Excellent recyclability and synthetic utility are observed in these palladium-catalyzed transformations.