楔前
丘脑
重性抑郁障碍
神经科学
额下回
眶额皮质
拓扑(电路)
额中回
动态功能连接
额上回
静息状态功能磁共振成像
心理学
功能磁共振成像
前额叶皮质
数学
认知
组合数学
作者
Yue Zhou,Yan Zhu,Hongting Ye,Wenhao Jiang,W. Zhang,Youyong Kong,Yonggui Yuan
标识
DOI:10.1016/j.jad.2023.10.143
摘要
Most studies have detected abnormalities of static topological characteristics in major depressive disorder (MDD). However, whether dynamic alternations in brain topology are influenced by MDD remains unknown.An approach was proposed to capture the dynamic topological characteristics with sliding-window and graph theory for a large data sample from the REST-meta-MDD project.It was shown that patients with MDD were characterized by decreased nodal efficiency of the left orbitofrontal cortex. The temporal variability of topological characteristics was focused on the left opercular part of inferior frontal gyrus, and the right part of middle frontal gyrus, inferior parietal gyrus, precuneus and thalamus.Future studies need larger and diverse samples to explore the relationship between dynamic topological network characteristics and MDD symptoms.The results support that the altered dynamic topology in cortex of frontal and parietal lobes and thalamus during resting-state activity may be involved in the neuropathological mechanism of MDD.
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