New bisabolane-type sesquiterpenoid from Aspergillus sydowii BTBU20213012

AbstractA new bisabolane-type sesquiterpenoid, named (+)-8-dehydroxylaustrosene (1), along with ten known compounds, penicibisabolanes E (2) and G (3), (+)-austrosene (4), (S)-(+)-11-dehydrosydonic acid (5), sydonic acid (6), (7S,11S)-(+)-12-hydroxysydonic acid (7), (−)-(R)-hydroxysydonic acid (8), pseudaboydin A (9), (−)-(7 R,10R)-iso-10-hydroxysydowic acid (10), lumichrome (11), were identified from the fungus Aspergillus sydowii BTBU20213012 isolated from a marine sediment sample from the Western Pacific. The structures of the compounds were identified by HRESIMS and NMR data analysis. Compound 11 showed weak antimicrobial activity against Staphylococcus aureus with MIC value of 200 μg/mL.Keywords: Marine-derived fungusAspergillus sydowiisesquiterpenoidStaphylococcus aureus Disclosure statementNo conflict of interest was reported by the authors.Additional informationFundingThis work was supported by grants from the Science and Technology Program of Tibet Autonomous Region (XZ202101YD0013C), the National Natural Science Foundation of China (81973204, 31960013), the State Key Laboratory of Silkworm Genome Biology, and Research Foundation for Advanced Talents of Beijing Technology and Business University (19008021176).