自愈水凝胶
纳米复合材料
碳纳米管
材料科学
药物输送
共价键
纳米技术
化学工程
苯硼酸
高分子化学
化学
有机化学
催化作用
工程类
作者
Boyan Li,Tung‐Yi Lin,Yi‐Jhen Lai,Ting‐Hsiang Chiu,Yi‐Cheun Yeh
出处
期刊:Small
[Wiley]
日期:2025-02-16
卷期号:21 (12): e2407420-e2407420
被引量:36
标识
DOI:10.1002/smll.202407420
摘要
Second near-infrared (NIR-II) responsive hydrogels have shown significant potential in biomedical applications due to their excellent remote actuation property and the high tissue penetrations of the NIR-II light. Nevertheless, hydrogels with a single NIR-II light response may not meet the diverse requirements and complex conditions of clinical applications. Here, a novel multi-responsive nanocomposite hydrogel with enhanced suitability for controlled drug release is developed. This nanocomposite hydrogel is constructed by combining alginate dialdehyde (ADA), polyethyleneimine (PEI), poly(N-isopropylacrylamide) (PNIPAM), and phenylboronic acid-modified polyethyleneimine (PBA-PEI) functionalized multi-walled carbon nanotubes (PP-CNT) through the formation of dynamic covalent bonds (i.e., imine bonds and boronate ester bonds), forming ADA/PEI/PNIPAM/PP-CNT (APN/PP-CNT) hydrogel. PNIPAM is incorporated into the hydrogel network to facilitate drug release triggered by its aggregation when subjected to the high temperatures produced by NIR-II light irradiation. The dynamic covalent bonds and CNT in the network provide the APN/PP-CNT nanocomposite hydrogels with responsiveness to multiple stimuli, including pH, hydrogen peroxide, temperature, and NIR-II light. The APN/PP-CNT nanocomposite hydrogel performs effective NIR-II light responsiveness in both in vitro and in vivo drug release, highlighting its potential as a promising drug delivery platform.
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