Signal Amplification by the trans-Cleavage Activity of CRISPR-Cas Systems: Kinetics and Performance

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSignal Amplification by the trans-Cleavage Activity of CRISPR-Cas Systems: Kinetics and PerformanceWei FengWei FengDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 10-102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3More by Wei FengView Biographyhttps://orcid.org/0000-0003-1081-7914, Hongquan ZhangHongquan ZhangDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 10-102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3More by Hongquan ZhangView Biographyhttps://orcid.org/0000-0003-1088-9862, and X. Chris Le*X. Chris LeDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 10-102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3*[email protected]More by X. Chris LeView Biographyhttps://orcid.org/0000-0002-7690-6701Cite this: Anal. Chem. 2023, 95, 1, 206–217Publication Date (Web):January 10, 2023Publication History Received16 October 2022Published online10 January 2023Published inissue 10 January 2023https://doi.org/10.1021/acs.analchem.2c04555Copyright © 2023 The Authors. Published by American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceCC: Creative CommonsBY: Credit must be given to the creatorNC: Only noncommercial uses of the work are permittedND: No derivatives or adaptations of the work are permittedArticle Views712Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (8 MB) Get e-AlertsSUBJECTS:Crystal cleavage,Genetics,Kinetics,Nucleic acids,Peptides and proteins Get e-Alerts