多路复用
肺癌
癌症
医学
肿瘤科
癌症研究
生物
内科学
计算生物学
生物信息学
作者
Hiroki Kanasaki,Yuichi Ozawa,Naoto Nakamura,KIMIHIKO NAGASAKI,Wataru Matsuyama,Daisuke Akahori,Mitsuru Niwa,TAKASHI OGASAWARA,Jun Sato
标识
DOI:10.21873/anticanres.16863
摘要
Background/Aim: Detection of genetic abnormalities is crucial for selecting an appropriate therapy to effectively treat advanced non-small cell lung cancer (NSCLC). Multiplex genetic testing aids the selection of appropriate therapy and tailored treatments; however, its impact on survival remains unexplored. Patients and Methods: Using data from 112 patients with advanced or recurrent NSCLC between February 2020 and April 2023, we investigated the impact of multiplex genetic tests, conducted before the initiation of systemic therapy, on survival. Results: Multiplex genetic test was performed on 72 patients (MPL group). Among the remaining 40 patients (non-MPL group), 18 underwent ≥1 single-plex genetic test, including tests for EGFR (18), ALK (14), and ROS1 (8). The frequency of EGFR mutations in the MPL and non-MPL groups was similar (28% and 25%, respectively), whereas alterations in KRAS, ALK, MET, HER2, and RET levels (5, 4, 4, 4, and 1, respectively) were exclusively detected in the MPL group. The MPL group exhibited a significantly improved survival rate compared to the non-MPL group (median survival time 20.6 vs. 9.3 months, p=0.009). Conclusion: Multiplex genetic testing, before the initiation of systemic treatment, could potentially enhance prognosis by uncovering a wide range of non-EGFR gene abnormalities. Multiplex genetic tests could be crucial for the effective application of modern anticancer therapeutic strategies.
科研通智能强力驱动
Strongly Powered by AbleSci AI