免疫疗法
免疫
免疫学
医学
三级护理
免疫系统
内科学
作者
Giulia Petroni,Serena Pillozzi,Lorenzo Antonuzzo
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2024-02-21
标识
DOI:10.1158/0008-5472.can-23-3325
摘要
Abstract Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non-small cell lung cancer. Although the detailed cellular and molecular mechanisms underlying these clinical associations have not been fully elucidated, growing preclinical and clinical studies are helping to elucidate the mechanisms at the basis of TLS formation, composition, and regulation of immune responses. However, a major challenge remains how to exploit TLS to enhance naïve and treatment-mediated antitumor immune responses. Here, we discuss the current understanding of tumor-associated TLS, preclinical models that can be used to study them, and potential therapeutic interventions to boost TLS formation, with a particular focus on lung cancer research.
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