体内
高分辨率
分辨率(逻辑)
材料科学
生物医学工程
纳米技术
计算机科学
工程类
遥感
地质学
人工智能
生物技术
生物
作者
Xiaobo Zhou,Fan Yi,Shijie Li,Ke Zhang,Yuetian Pei,Yuhan Zeng,Xiaoxia Kang,Lingfeng Zhao,Hao Chen,Yuling Qin,Wei Feng,Lingxiao Liu,Li Wu
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-01-26
卷期号:24 (5): 1792-1800
被引量:1
标识
DOI:10.1021/acs.nanolett.3c04976
摘要
A comprehensive approach for the construction of NIR-I/NIR-II nanofluorophores with exceptional brightness and excellent chemo- and photostability has been developed. This study first confirmed that the amphiphilic molecules with stronger hydrophobic moieties and weaker hydrophilic moieties are superior candidates for constructing brighter nanofluorophores, which are attributed to its higher efficiency in suppressing the intramolecular charge transfer/aggregation-caused fluorescence quenching of donor-acceptor-donor type fluorophores. The prepared nanofluorophore demonstrates a fluorescence quantum yield exceeding 4.5% in aqueous solution and exhibits a strong NIR-II tail emission up to 1300 nm. The superior performance of the nanofluorophore enabled the achievement of high-resolution whole-body vessel imaging and brain vessel imaging, as well as high-contrast fluorescence imaging of the lymphatic system in vivo. Furthermore, their potential for highly sensitive fluorescence detection of tiny tumors in vivo has been successfully confirmed, thus supporting their future applications in precise fluorescence imaging-guided surgery in the early stages of cancer.
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