免疫分析
聚乙二醇
药方
医学
液相色谱-质谱法
内科学
色谱法
化学
药理学
质谱法
免疫学
抗体
生物化学
作者
Gergely Talabér,Tomas Meisel,Thord Rosén
出处
期刊:Labmedicine
[Oxford University Press]
日期:2022-10-12
卷期号:54 (4): e111-e113
标识
DOI:10.1093/labmed/lmac136
摘要
Falsely increased estradiol levels can lead to unnecessary tests and therapeutic interventions. Here, we present a case of a 62-year-old man with falsely elevated estradiol, which led to subsequent follow-up testing and prescriptions. Alternative immunoassay testing, in conjunction with Scantibodies' blocking reagents, polyethylene glycol precipitation, and liquid chromatography-tandem mass spectrometry confirmation demonstrated that the falsely elevated estradiol was due to the presence of macro-estradiol. This report emphasizes the importance of recognizing analytical interferences in immunoassays to appropriately manage subsequent testing and patient care.
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