缺血
氧化应激
药理学
结扎
医学
糖原磷酸化酶
细胞凋亡
再灌注损伤
颈动脉
糖原
脑缺血
颈总动脉
麻醉
化学
内科学
生物化学
作者
Zhiwei Yan,Shuai Li,Youde Wang,Yachun Guo,Liying Zhang
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2023-04-01
卷期号:15 (7): 587-597
标识
DOI:10.4155/fmc-2023-0038
摘要
Aim: To evaluate the effects of a novel glycogen phosphorylase inhibitor (NGPI) on cerebral ischemia-reperfusion injury (CIRI). Methods: Cerebral ischemia was induced in mice using a modified bilateral common carotid artery ligation model. To assess the effects of NGPI against CIRI, mice which had been administered with different doses of NGPI (1.25, 2.5, 5 mg/kg/day) for 7 days before the injury were evaluated for infarct volume, the apoptosis level of brain tissue, integrity of brain tissue and oxidative stress level. Results: NGPI effectively improved the infarct area, apoptosis of neurons, integrity of brain tissue and oxidative stress level of mice with CIRI. Conclusion: NGPI could effectively improve CIRI and deserves further study.
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