抗菌剂
粪肠球菌
化学
细胞毒性
大肠杆菌
白色念珠菌
离子液体
部分
屎肠球菌
细菌
微生物学
立体化学
有机化学
生物化学
体外
生物
抗生素
催化作用
基因
遗传学
作者
Łukasz Pałkowski,Maciej Karolak,Andrzej Skrzypczak,Marta Wojcieszak,Filip Walkiewicz,Jonasz Podemski,Karol Jaroch,Barbara Bojko,Katarzyna Materna,Jerzy Krysiński
出处
期刊:Molecules
[MDPI AG]
日期:2022-03-18
卷期号:27 (6): 1974-1974
被引量:8
标识
DOI:10.3390/molecules27061974
摘要
In this study, a series of 10 novel 1-methyl-3-octyloxymethylimidazolium derivatives carrying various anionic moieties (4-hydroxybenzenesulfonate, benzenesulfonate, carvacroloxyacetate, chloride, formate, propionate, thymoloxyacetate, vanillinoxyacetate, eugenoloxyacetate and trimethylacetate) were synthesized. Compounds were tested for their antimicrobial activity against six microbe strains (Staph-ylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis, and Candida albicans), cytotoxic activity against the mouse melanoma cell line (B16 F10), and surface active properties. All synthesized compounds exhibited antimicrobial activity (expressed as minimum inhibitory concentration; in range of 0.10-27.82 mM/L), especially against Gram-positive bacteria and fungi. In addition, all compounds demonstrated cytotoxicity on B16 F10 cells (IC50 values 0.0101-0.0197 mM/L). Surface properties defined as CMC values, ranged from 0.72 to 32.35 mmol L-1. The obtained results provide an insight into the promising activity of a novel group of quaternary imidazolium derivatives having ionic liquid properties. The most potent compounds, containing a thymoloxyacetate and eugenoloxyacetate moiety, could be candidates for new antimicrobial agents or surfactants.
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