低尿酸血症
高尿酸血症
尿酸
痛风
无症状的
医学
肾脏疾病
有机阴离子转运蛋白1
内科学
内分泌学
运输机
生物
生物化学
基因
作者
Naoyuki Otani,Motoshi Ouchi,Kazuharu Misawa,Ichiro Hisatome,Naohiko Anzai
出处
期刊:Biomedicines
[MDPI AG]
日期:2022-03-11
卷期号:10 (3): 652-652
被引量:16
标识
DOI:10.3390/biomedicines10030652
摘要
Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0 mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction type. The former typical disease is xanthinuria, and the latter is renal hypouricemia (RHUC). The frequency of nephrogenic hypouricemia due to a deficiency of URAT1 is high in Japan, accounting for most asymptomatic and persistent cases of hypouricemia. RHUC results in a high risk of exercise-induced acute kidney injury and urolithiasis. It is vital to promote research on RHUC, as this will lead not only to the elucidation of its pathophysiology but also to the development of new treatments for gout and hyperuricemia.
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