聚氨酯
材料科学
多元醇
离子键合
化学工程
共轭体系
聚合物
极限抗拉强度
可生物降解聚合物
二醇
高分子化学
增塑剂
生物相容性
核化学
复合材料
有机化学
化学
离子
冶金
工程类
作者
Younghyun Ryu,Seong-Min Choi,Dohyun Oh,Sung-Wook Choi
标识
DOI:10.1007/s13233-022-0014-z
摘要
Biodegradable and hydrophilic poly(ε-caprolactone) (PCL)-based polyurethane (PU) dispersion was synthesized using PCL diol as the first polyol by a pre-polymer method. Dimethylol propionic acid (DMPA) was used as the polyol to provide carboxyl groups in PU and enhance the hydrophilicity of the resultant PU film. The carboxyl groups of the waterborne PU were utilized for the conjugation with alendronate (Alen) and the ionic cross-linking among PU polymers by calcium chloride. Both the Alen conjugation and ionic cross-linking significantly reduced the water contact angle. The Alen-conjugated PU (Alen-PU) film without ionic cross-linking exhibited a ductile characteristic with high elongation at break. The ionic cross-linking of the Alen-PU film resulted in the enhancement of Young’s modulus and tensile strength. In addition, the ionic cross-linking increased the biodegradation time of the PU-based films. The employment of Alen in PU film led to the lower proliferation and higher differentiation of pre-osteoblastic cells (MC3T3-E1) than PU film. We believed that the Alen-PU films have the potential for widespread application in tissue engineering, especially for guided bone regeneration.
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