Defining Autoimmunity and Autoimmune Disease The Discovery and Rediscovery of Autoimmunity Mechanisms of Tolerance Genetics as a Factor in Autoimmune Disease Susceptibility Environmental Factors and Autoimmune Disease The Effects of Immune Disregulation on Autoimmune Disease Development Mechanisms of Tissue Destruction and Organ Damage in Autoimmune Diseases Experimental Animal Models of Autoimmunity Autoimmunity through Immunization Treatment Strategies for Autoimmune Disease Conclusion