工件(错误)
生物医学中的光声成像
声学显微镜
材料科学
生物医学工程
反射(计算机编程)
成像体模
超声波传感器
显微镜
显微镜
神经影像学
光学
声学
计算机科学
计算机视觉
医学
物理
精神科
程序设计语言
作者
Wentian Chen,Chao Tao,Zizhong Hu,Songtao Yuan,Qinghuai Liu,Xiaojun Liu
出处
期刊:Chinese Physics B
[IOP Publishing]
日期:2022-04-01
卷期号:31 (4): 044304-044304
被引量:2
标识
DOI:10.1088/1674-1056/ac4a6f
摘要
Photoacoustic imaging is a potential candidate for in vivo brain imaging, whereas, its imaging performance could be degraded by inhomogeneous multi-layered media, consisted of scalp and skull. In this work, we propose a low-artifact photoacoustic microscopy (LAPAM) scheme, which combines conventional acoustic-resolution photoacoustic microscopy with scanning acoustic microscopy to suppress the reflection artifacts induced by multi-layers. Based on similar propagation characteristics of photoacoustic signals and ultrasonic echoes, the ultrasonic echoes can be employed as the filters to suppress the reflection artifacts to obtain low-artifact photoacoustic images. Phantom experiment is used to validate the effectiveness of this method. Furthermore, LAPAM is applied for in-vivo imaging mouse brain without removing the scalp and the skull. Experimental results show that the proposed method successfully achieves the low-artifact brain image, which demonstrates the practical applicability of LAPAM. This work might improve the photoacoustic imaging quality in many biomedical applications which involve tissues with complex acoustic properties, such as brain imaging through scalp and skull.
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