淋巴母细胞
染色体易位
甲氨蝶呤
祖细胞
白血病
急性淋巴细胞白血病
癌症研究
肿瘤科
医学
费城染色体
祖细胞
染色体
内科学
生物
免疫学
淋巴细胞白血病
干细胞
遗传学
细胞培养
基因
作者
V. Michael Whitehead,M J Vuchich,Linda D. Cooley,S J Lauer,Donald H. Mahoney,Jonathan J. Shuster,C Payment,Mark L. Bernstein,J Akabutu,Thomas J. Bowen,Barton A. Kamen,Michael S. Watson,A. Thomas Look,DJ Pullen,Bruce M. Camitta
出处
期刊:PubMed
日期:1998-01-01
卷期号:4 (1): 183-8
被引量:4
摘要
Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate (MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of their blast cells to MTX. However, the proportion of children who are cured of B-progenitor cell acute lymphoblastic leukemia exceeds the number whose lymphoblasts accumulate high MTXPG levels. We report that lymphoblasts from patients with < 50 chromosomes who have translocations that involve the short arm of chromosome 12 accumulate low levels of MTXPGs. These patients appear to have an excellent survival because none of 14 patients with translocations affecting 12p has relapsed, 26-79 months following diagnosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI