脂联素
神经发生
抗抑郁药
海马结构
神经科学
医学
体育锻炼
海马体
中枢神经系统
内科学
生物信息学
心理学
生物
肥胖
胰岛素抵抗
作者
Ang Li,Suk-Yu Yau,Sérgio Machado,Ti‐Fei Yuan,Kwok–Fai So
出处
期刊:Cns & Neurological Disorders-drug Targets
[Bentham Science Publishers]
日期:2015-11-27
卷期号:14 (9): 1129-1144
被引量:11
标识
DOI:10.2174/1871527315666151111125533
摘要
Physical exercise has long been recognized to benefit locomotor and cardiovascular systems. Although an increasing body of evidence also suggests it to be an effective non-medicinal remedy for mental disorders such as depression, the underlying mechanisms remain elusive. A recent study has demonstrated that increases of the adipocytesecreted hormone adiponectin in the central nervous system following exercise may be responsible for these neuropsychological changes, including enhanced generation of neurons in the adult hippocampus, as well as mitigation of depressive severity. The present review introduces the previously-reported functions of adult hippocampal neurogenesis and adiponectin, and discusses the potential relevance of adiponectin signaling in exercise-induced neural changes. Revealing these novel biological effects of adiponectin in the brain may help hunt reliable biomarkers to better guide the anti-depressive therapy with exercise intervention; meanwhile, pharmaceutical agents that raise endogenous levels of adiponectin or mimic its biological effects might serve as a replacement for physical exercise. Keywords: Adult neurogenesis, hippocampus, adiponectin, depression, physical exercise.
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