聚酮
碳骨架
骨架(计算机编程)
立体化学
化学
链霉菌
生物合成
生物
有机化学
细菌
酶
解剖
遗传学
作者
Regina Höfs,Martina Walker,Axel Zeeck
标识
DOI:10.1002/1521-3773(20000915)39:18<3258::aid-anie3258>3.0.co;2-q
摘要
An unusual type I polyketide defined in a unique hexacyclic skeleton was determined as the structure of hexacyclinic acid (1). The structure was elucidated by X-ray analysis in connection with chemical–spectroscopic methods, and the biosynthesis was explored through feeding experiments with 13C-labeled precursors. The compound was isolated by application of the OSMAC approach to Streptomyces cellulosae S 1013.
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