PLGA公司
材料科学
超临界流体
聚合物
溶剂
可生物降解聚合物
化学工程
降水
乙醇酸
布比卡因
核化学
乳酸
有机化学
纳米技术
复合材料
化学
纳米颗粒
医学
外科
气象学
工程类
物理
细菌
生物
遗传学
作者
S. Lee,M. S. Kim,J. S. Kim,H. J. Park,Jong Soo Woo,B. C. Lee,Sung Joo Hwang
标识
DOI:10.1080/09687860600945552
摘要
The purpose of this study was to prepare microspheres loaded with hydrophilic drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA ratio with two different levels of bupivacaine HCl (5 and 10%) using a supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 microm in geometric mean diameter could be prepared, with high loading efficiency. Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its crystalline state within the polymer and was present as a dispersion within the polymer phase after SAS processing. The release of bupivacaine HCl from biodegradable polymer microspheres was rapid up to 4 h, thereafter bupivacaine HCl was continuously and slowly released for at least 7 days according to the PLGA/PLLA ratio and the molecular weight of PLLA.
科研通智能强力驱动
Strongly Powered by AbleSci AI