拟南芥
生物钟
生物
转录因子
遗传学
心理压抑
功能基因组学
细胞生物学
计算生物学
基因
基因组学
基因表达
突变体
基因组
作者
José L. Pruneda-Paz,Ghislaı̀n Breton,Alessia Para,Steve A. Kay
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2009-03-13
卷期号:323 (5920): 1481-1485
被引量:409
标识
DOI:10.1126/science.1167206
摘要
Transcriptional feedback loops constitute the molecular circuitry of the plant circadian clock. In Arabidopsis , a core loop is established between CCA1 and TOC1. Although CCA1 directly represses TOC1 , the TOC1 protein has no DNA binding domains, which suggests that it cannot directly regulate CCA1 . We established a functional genomic strategy that led to the identification of CHE, a TCP transcription factor that binds specifically to the CCA1 promoter. CHE is a clock component partially redundant with LHY in the repression of CCA1 . The expression of CHE is regulated by CCA1, thus adding a CCA1/CHE feedback loop to the Arabidopsis circadian network. Because CHE and TOC1 interact, and CHE binds to the CCA1 promoter, a molecular linkage between TOC1 and CCA1 gene regulation is established.
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