SUCCESSIVE SHORT GLYCYL SEQUENCE PROHIBITING FORMATION OF ASSOCIATED β-STRUCTURE IN THE PRECIPITATION

Abstract A peptide consisting of l-alanine and l-leucine, Nps-(l-Leu-l-Leu-l-Ala)4-OEt takes β-Structure in spite of its peptide length above the critical peptide length for the formation of α-helix in the solid state. Introduction of successive short glycyl residues to the terminal position of the peptide prevents the formation of the β-structure to develop the α-helix of the peptide.