转铁蛋白受体
铁蛋白
结直肠癌
转铁蛋白
免疫组织化学
癌
病理
医学
淋巴结
内科学
腺癌
癌症研究
生物
癌症
作者
Maja Prutki,Marija Poljak-Blaži,Marko Jakopovic,Davor Tomas,Igor Stipančić,Neven Zarkovic
出处
期刊:Cancer Letters
[Elsevier]
日期:2006-07-01
卷期号:238 (2): 188-196
被引量:94
标识
DOI:10.1016/j.canlet.2005.07.001
摘要
In this study, the level and distribution of transferrin receptor 1 (TfR1) and ferritin in colorectal carcinoma and in normal colon epithelium has been determined relative to the tumor stage and iron status of patients using immunohistochemical staining methods. While the majority of carcinoma patients were anemic, no relationship between the level of colon tissue ferritin and TfR1 and the systemic parameters of iron metabolism was evident. Furthermore, no association between ferritin content and the grade of colorectal carcinoma was observed. However, a relationship between the expression of TfR1 and the grade of colorectal carcinoma was observed. In this case high expression of TfR1 was found in colorectal carcinoma samples of Dukes A or B grade, and well differentiated colorectal carcinoma cells. In comparison, weak or no expression of TfR1 was observed in carcinoma samples of Dukes C or D grade with poorly differentiated cells and in carcinoma samples that had lymph node infiltration and distant metastasis.
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