Differential Effects of ω-Conotoxin GVIA, Tetrodotoxin and Prolonged Cold Storage on Purinergic and Adrenergic Transmission in Isolated Canine Splenic Artery

(1) omega-CTX-sensitive calcium channels may produce a parallel modulation of purinergic and adrenergic components of sympathetic cotransmission; (2) TTX-sensitive sodium channels may have a more important role in controlling the adrenergic rather than purinergic transmission; and (3) the function of purinergic transmission of sympathetic nerve might be affected more strongly than that of adrenergic transmission in the cold-stored canine splenic artery.