过剩1
葡萄糖转运蛋白
癌细胞
化学
癌症
碳水化合物代谢
运输机
生物化学
新陈代谢
细胞
葡萄糖摄取
生物
内科学
内分泌学
基因
医学
胰岛素
作者
Alexandra Brito,Patrícia M. R. Pereira,Diana Soares da Costa,Rui L. Reis,Rein V. Ulijn,Jason S. Lewis,Ricardo A. Pires,Iva Pashkuleva
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2020-01-01
卷期号:11 (14): 3737-3744
被引量:20
摘要
We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the cell surface through localized (biocatalytic) self-assembly. We demonstrate that the expression of the cancer associated GLUT1 and alkaline phosphatase are crucial for the effectiveness of this combined approach: cancer cells that overexpress both proteins are prompter to cell death when compared to GLUT1 overexpressing cells. Overall, we showcase that the synergism between physical and biochemical deprivation of cancer metabolism is a powerful approach for development of effective anticancer therapies.
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