神经退行性变
线粒体
戒毒(替代医学)
生物能学
粒线体疾病
生物信息学
计算生物学
神经科学
生物
线粒体DNA
医学
疾病
遗传学
病理
基因
替代医学
作者
Luíz Henrique Marchesi Bozi,Juliane C. Campos,Vanessa O. Zambelli,Nikolas D. Ferreira,Julio Cesar Batista Ferreira
标识
DOI:10.1016/j.mam.2019.100836
摘要
Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases (mitochondriopathies) and many other infectious and non-infectious diseases including viral, bacterial and protozoan infections, inflammatory and chronic pain, neurodegeneration, diabetes, obesity and cardiovascular diseases. Mitochondria therefore become an attractive target for developing new therapies. In this review we describe critical mechanisms involved in the maintenance of mitochondrial functionality and discuss strategies used to identify and validate mitochondrial targets in different diseases. We also highlight the most recent preclinical and clinical findings using molecules targeting mitochondrial bioenergetics, morphology, number, content and detoxification systems in common pathologies.
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