药物输送
癌细胞
淋巴瘤
癌症
免疫系统
医学
癌症研究
化疗
靶向给药
药品
抗药性
药理学
免疫学
纳米技术
内科学
生物
材料科学
微生物学
作者
Qiangqiang Zhao,Xiaoying Sun,Bin Wu,Yilun Shang,Xueyuan Huang,Hang Dong,Haiting Liu,Wansong Chen,Rong Gui,Jian Li
标识
DOI:10.1186/s12951-020-00738-8
摘要
Abstract Background Non-Hodgkin’s lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells. Results Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis. Conclusions Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.
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