Research advances in transition metal catalysts of Sonogashira cross-coupling reaction

Sonogashira cross-coupling reaction is one of the most important reactions of forming new C—C bond and alkynylation,and metal catalysts play an important role.In this paper the application of various transition metals as catalyst in the Sonogashira cross-coupling reaction is reviewed.Meanwhile,the application of palladium catalysts in green Sonogashira cross-coupling reaction and other transition metal catalysts in Sonogashira cross-coupling reaction are introduced.Pd/C catalyst may be a new candidate in the industrial application of Sonogashira cross-coupling reaction,and water,suitable catalyst system and alkaline system play an essential role in improving environmental compatibility.