Asymmetric synthesis of 2S,7S-diaminosuberic acid with glycine equivalent method

2S,7S-Diaminosuberic acid was asymmetrically synthesized by reacting Gly-Ni-2[N-(N′-benzylprolyl)amino]benzophenone as the chiral auxiliary with 1,4-dibromobutane.The effect of the molar ratio of Ni(Ⅱ) complexes of glycine Schiff base to 1,4-dibromobutane and the reaction time on the yield of intermediates was investigated.The optimal reaction conditions were determined as follows:a molar ratio of 1:0.5,and a reaction time of 10 min.The yield of 2S,7S-diaminosuberic acid was 63%.All products were characterized by NMR,MS,and optical rotation technique.