Objective: To study the effect of Chang Yan Ping Granular on the effect of anti-ulcerative colitis.Methods: An experimental model of acute ulcerative colitis rats was made by chemical substance to observe the effect and an experimental model of chronic ulcerative colitis rats was made to observe the effect.Results: Chang Yan Ping Granular could effectively inhibit the generation of the experimental acute ulcerative colitis and improve the healing and restoration of the experimental chronic ulcerative colitis.Conclusion: The effect of the anti-ulcerative colitis of Chang Yan Ping Granular provides an effective theoretic basis for its clinical treatment of ulcerative colitis patients.