THE EXPRESSION OF SONIC HEDGEHOG AND ITS SIGNIFICANCE IN THE DEVELOPMENT OF INTESTINAL-TYPE GASTRIC CANCER

Objective To investigate the expression of sonic hedgehog(SHH) in development of intestinal-type gastric cancer and its correlation with CDX2.Methods Using immunohistochemical method,the expressions of SHH and CDX2 in chronic superficial gastritis(CSG),chronic atrophic gastritis(CAG) with intestinal metaplasia(IM),atypical hyperplasia and intestinal-type gastric cancer(ITGC) were detected.Results The expression rate of SHH in CAG with IM was lower than that in CSG(χ2=3.914,P0.05),in ITGC,the expression of SHH was higher than in CSG(χ2=10.286,P0.05).CDX2 was not detected in CSG.The positive CDX2 expression in CAG with IM was higher than that in atypical hyperplasia and ITGC(χ2=9.619,4.904;P0.05).The expression of SHH was negatively correlated with that of CDX2 in CAG with IM(r=-0.384,P0.05).Conclusion SHH is associated with intestinal metaplasia of gastric mucosa and the development of ITGC,in the process of the intestinal metaplasia,an interaction between SHH and CDX2 may take place.