精氨酸
医学
丙二醛
心肌梗塞
氧化应激
黄嘌呤氧化酶
内科学
超氧化物歧化酶
肌钙蛋白
肌钙蛋白I
肌钙蛋白T
抗氧化剂
缺血
心脏病学
内分泌学
生物化学
化学
酶
氨基酸
作者
Pratima Tripathi,Tejbir Singh,M. Chandra,M. K. Misra
摘要
Ischemic heart is a leading cause of death all over the world. Therapeutic role of L-arginine in overcoming the oxidative stress during myocardial ischemia is still not clear. In the present work, effect of L- arginine supplementation to the patients of acute myocardial infarction has been studied.
Subjects were randomly divided into four groups: control, control with L-arginine supplementation, patients with acute myocardial infarction (AMI) and patients with acute myocardial infarction with L-arginine supplementation. Subjects were given oral dose of L-Arg (3g/day) for fifteen days. Oxidative stress indices [Xanthine oxidase (XO) and malondialdehyde (MDA)] and antioxidant indices [Superoxide dismutase (SOD) and total thiols (T-SH)] in the erythrocytes and serum cardiac markers CPK-MB and Troponin-T were monitored before and at the end of L-arginine therapy.
L-arginine supplementation increased T-SH content significantly in treated patients (p<0.001). XO activity, upon L-arginine supplementation, decreased by 31% (p<0.005) in the patients. Also, we noted significant reduction in the levels of serum cardiac markers; CPK-MB and Troponin T in the AMI patients receiving L-arginine therapy (p<0.001)
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